Volume 6 Number 1

Editor’s Note

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Review Articles

Obstructive sleep apnoea hypopnoea syndrome – an overview.
Wan Haniza Wan Mohamad, Tengku Saifudin Tengku Ismail

Haematinics for anaemia in the elderly.
Khoo Siew Beng

Original Articles

Effectiveness of computerized visual screening tool used in driving schools in Malaysia.
Haliza Abdul Mutalib, Md Muziman Syah Md Mustafa Syah, Norliza Mohammad Fadzil

A comparison of morbidity patterns in public and private primary care clinics in Malaysia.
Mimi Omar, Tong Seng Fah, Nordin Saleh, Teng Cheong Lieng, Khoo Ee Ming, Abdul Kareem Abdul Rahman, Zailinawati Abu Hassan, Verna Lee Kar Mun, Chen Wei Seng, Wan Mohd Shihabudin Wan Mamat, Noridah Mohd Salleh, Fauziah Zainal Ehsan

Case Reports

Palliative care for a child: role of a primary care doctor.
Tan Chai Eng, Mohd Radzniwan Rashid, Khairani Omar, Ednin Hamzah.

The blue man who presented with a stroke.
Koh Kwee Choy, Wong Mun Hoe.

Pre-auricular sinus: an uncommon presentation.
Johnson Ng Wei Siang, Chew Yok Kuan, Tan Keng Lu, Chong Aun Wee

of the proapoptotic Bcl 2 family protein, Bax (Figure 1d). Authenitc Red Johnny Gaudreau Jersey Figure Kid Mason Raymond Jersey 1. Characterization of the apoptotic response to neglect in HeLa cells. (a) Confocal image of HeLa cells cultured in complete medium (CM; nutrient replete) or buffered Authenitc White Rasmus Andersson Jersey saline (neglect). After 6 cells were harvested and assessed for apoptotic changes using Hoechst 33 or by the TUNEL Elite Red Devin Setoguchi Jersey assay; scale bar: 5 (b) Quantitation of apoptotic nuclear Elite Red Miikka Kiprusoff Jersey damage as assessed by Women TJ Brodie Jersey the two readouts, described in panel a, from three separate experiments. (c) Phosphatidylserine exposure assessed using Annexin V FITC in HeLa cells at the onset of the assay (t Men Devin Setoguchi Jersey and after culture in buffered saline Kid Mason Raymond Jersey for 6 (neglect). Women TJ Brodie Jersey (d) HeLa cells were treated with siRNA to Kid Mason Raymond Jersey Bax, or a scrambled control for 48 Cells were Kid Miikka Kiprusoff Jersey continued Elite White TJ Brodie Authenitc Red Kris Russell Jersey Jersey in CM or buffered Elite White Dennis Wideman Jersey saline, and apoptotic nuclear Elite TJ Brodie Jersey damage was Elite White Kris Russell Jersey assessed after 6 The western blot shows the levels of Bax protein in siRNA treated groups. Data from three Women Devin Setoguchi Jersey independent experiments are Authenitc White Jarome Iginla Jersey plotted Full figure and legend (175K) Ligand dependent
we have concluded that this resolution is best for the Vikings and for Adrian,” the statement added. “We want to be clear: Authenitc White Dennis Wideman Jersey we have a strong stance regarding the protection and welfare of children, and we want to be sure we get Elite Devin Setoguchi Jersey this right. “We will support Adrian during this legal and personal process, but we firmly believe and realise this is the right decision.” Ray Rice, pictured with his wife, was initially suspended for two games by the NFL but eventually his contract was terminatedNike confirmed that they have suspended their contract with Peterson in a statement which said: “Nike in no way condones child abuse or domestic violence of any kind and we have shared our concerns with the NFL.” Hotel chain Radisson suspended its sponsorship of the Vikings as a result of the charges. The Peterson controversy is the latest in the NFL and comes after Baltimore Ravens terminated the contract of running back Ray Rice following the release of a video appearing to

Test Your Knowledge

An adult patient with nail abnormality.
Koh Kwee Choy.

A clerk with back pain.
Esha Das Gupta, Nalini Somaweera.

A still born baby with cranial vault defects.
Loh Keng Yin, Nazimah Idris

Guidelines

Management of hypertension.
Abdul Rashid A Rahman, Khalid Yusoff, Chia Yook Chin.

Management of major depressive disorder (MDD).
Lim Chong Hum, Baizury Bashah.

MFP Reviewers 2011

Book Review

Conference abstract: MFP Volume 6 Supplement 1

15th Family Medicine Specialist Association Scientific Conference held at The Royale Bintang Resort & Spa, Seremban. 23-26 June 2011. [WebExtra]

functional interactions with mTOR Rictor and Akt identify a novel Notch mediated signaling cascade that favors cell survival. Top of Kid Mason Raymond Jersey Elite White Kris Russell Jersey pageResultsCharacterization of deprivation (neglect) induced Youth Dennis Wideman Jersey deathIf growth medium Authenitc Red Brandon Bollig Jersey is replaced by buffered saline, HeLa cells in culture undergo apoptosis Elite Red TJ Brodie Authenitc Jarome Iginla Jersey Jersey within 6 (neglect induced death). Apoptotic nuclear damage was determined Elite Red Devin Setoguchi Jersey using Hoechst 33 to reveal changes in morphology and Men Miikka Kiprusoff Jersey the TUNEL assay to detect double stranded breaks in cells (Figure 1a). The TUNEL assay gave comparable results to that obtained with Hoechst Women TJ Elite Red Johnny Gaudreau Jersey Brodie Jersey 33 (Figure 1b), and in all subsequent analysis, the assessment of nuclear Authenitc White Kris Russell Jersey morphology using Hoechst has been presented as the readout of Elite Youth Miikka Kiprusoff Jersey Elite White Dennis Wideman Jersey Red Devin Setoguchi Jersey damage. Dying cells were also characterized by the externalization of phosphatidylserine (Figure Women TJ Brodie Jersey Authenitc Rasmus Andersson Jersey 1c). Induction of apoptotic Authenitc White Brandon Bollig Jersey damage Women Devin Setoguchi Jersey was detected after 3 of deprivation and increased substantially by 6 (Supplementary Figure 1A). Furthermore, apoptosis was abrogated in cells following the siRNA mediated depletion
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